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 Recovery or replacement of bone tissue
Project leader: Prof John A. Jansen, PhD
Radboud University Nijmegen Medical Centre
Budget: € 6.700.000
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Replace or repair bones?
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| The world population is growing and on average we all live longer. The latter is positive for man and mankind, but it also results in an increased incidence of age-related diseases. Therefore, there is a demand for pro-active healthcare. One of the expectations is an increased need for possibilities to replace or repair damaged or lost body parts. For the musculoskeletal system this means more and improved bone-substituting and bone-recovering materials and coatings for implants. Materials that actively prompt and reinforce the process of bone formation. |
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© BMM / Rogier Trompert Medical Art
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Biomaterials in living tissue
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To remedy bone defects, new natural and synthetic materials are needed to stimulate the formation of bone tissue. That is the essence of this research. We also intend to improve the biological effect of these materials by varying their properties. In order to achieve rapid progress and apply it in the clinic, it is imperative that we can make predictions about the biological effect. Therefore, aside from the development of improved materials for application in bone implantation, work is now underway on a so-called high-throughput system, which would make it possible to conduct large numbers of experiments simultaneously and rapidly. In this way, a predictive value could be given to materials for their probable biological effect.
The project also focuses on developing coatings that would provide good adherence of the metal or synthetic implant with the surrounding tissue. We are also looking at the possibility of treating an implant or coating with certain biological substances. In that case, an implant would stay in place longer or be completely replaced by native bone. |
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Partners
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The following companies and institutes work together to make a success of BONE-IP:
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Publications
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- Alghamdi HS, A J A van Oirschot B, Bosco R, van den Beucken JJ, Aldosari AA, Anil S, Jansen JA. Biological response to titanium implants coated with nanocrystals calcium phosphate or type 1 collagen in a dog model. Clin Oral Implants Res. 2012 Jan 26. [Epub ahead of print]
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Thesis
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- Barbieri D, Instructive composites for bone regeneration. PhD Thesis, University of Twente, Enschede, Netherlands, 2012.
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