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 NEW BLOOD VESSELS FOR VASCULAR ACCESS IN HAEMODIALYSIS
Project leader: Joris I. Rotmans, PhD, nephrologist
Leiden University Medical Center
Budget: € 1.300.000
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Limited access
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| In haemodialysis, access to the bloodstream is needed to transport the patient’s blood to the artificial kidney. Naturally, the blood must be brought back into the patient’s body after purification by the artificial kidney. Blood vessels in the forearm are used to access the bloodstream with each dialysis. However, since a dialysis patient must undergo dialysis very often, frequently three times a week, the blood vessels become damaged and in the end suitable blood vessels are no longer available. Would the development of new, artificial blood vessels by tissue engineering from the patient’s own tissue contribute to better vascular access for haemodialysis? |
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© BMM / Rogier Trompert Medical Art
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Body’s ability to build new blood vessels
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| In this project we are developing a method that uses the body’s natural immune response to a plastic tube that is placed directly under the skin. The tissue formed around this tube largely consists of building materials that are also needed to form normal blood vessels. By removing this tube and introducing the newly formed tissue in the bloodstream, it will develop itself into a new blood vessel that can serve as vascular access. Special attention is needed to provide for sufficient elasticity and strength of the tissue since this is an important factor in the sustainable and prolonged use as vascular access. Effectiveness and safety are being investigated in prototypes, after which a start can be made with the necessary clinical studies. |
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Partners
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the following companies and istitutes work together to make a success of DialysisXS:
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Book chapters
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- JI Rotmans. Vascular tissue engineering. In ‘Best Practice in Vascular Access’, edited by J Tordoir. Edizioni Minerva Medica (2010). Abstract
- JI Rotmans and JH Campbell. Tissue engineering of small-diameter vascular grafts. Search for the Holy Grail. In ‘Biointegration of medical implants: science and design’. (2010). Published:August 13, 2010 by CRC Press - 384 Pages Editor(s):C. P. Sharma, Sree Chitra Tirunal Institute for Medical Sciences and Technology, India. Abstract
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Contact
BioMedical Materials
Urmonderbaan 20/A
NL-6167 RD GELEEN
NETHERLANDS
T +31 (46) 702 2280
E info@bmm-program.nl
Last updated on 2012-08-13