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 ZEBRAFISH FOR BETTER BIOMEDICAL MATERIALS
Project leader: Bas A.J. Zaat, PhD
Academic Medical Center Amsterdam
Budget: € 2.000.000
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Not native
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| In medicine, biomaterials that are brought into the human body for a short or long period of time have been used for years. Artificial hips, pacemakers and artificial heart valves save the lives of many, but nevertheless there are still major challenges. The human body often appears to defend itself against these materials because they are not ‘native’ and serious infections may develop. In many cases, this problem is difficult to predict and is only discovered at a late stage. This makes the quest for better solutions difficult and protracted, not to mention expensive. |
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© BMM / Rogier Trompert Medical Art
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‘Built-in’ screening
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| In the IBIZA project (Imaging of Biomaterial-associated Inflammation and Infection using Zebrafish) a high-througput screening model will be developed that can immediately visualize and analyse immune responses and infections in zebrafish. Zebrafish in the development stage are transparent, so reactions and infections can easily be traced under the microscope. Moreover, with this model targeted and controlled release of new medicines in the body can be imaged. The genetic overlap between zebrafish and man enables the valid translation of results. Thereby the IBIZA project will contribute significantly in speeding up the development of biomaterials. |
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Partners
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The following companies and institutes work together to make a success of IBIZA:
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Publications
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- Veneman WJ, Stockhammer OW, Boer L de, Zaat SAJ, Meijer AH, Spaink HP. A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery. BMC Genomics 2013, 14:255.
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Contact
BioMedical Materials
Urmonderbaan 20/A
NL-6167 RD GELEEN
NETHERLANDS
T +31 (46) 702 2280
E info@bmm-program.nl
Last updated on 2013-05-16